The diagnosis of hydrocephalus and shunt malfunction can be difficult and often requires more information than can be provided by MRI, CT, or ultrasound. Our St Louis investigator, Dr David Limbrick has begun the search for biomarkers of hydrocephalus and shunt malfunction. He is testing CSF and blood from infants suffering from post-hemorrhagic hydrocephalus in order to identify proteins that can be used for early diagnosis. In addition these proteins may provide real-time feedback on the effectiveness of treatment. Ultimately, we hope that these or similar biomarkers will provide a tool to complement current imaging methods and facilitate the diagnosis and treatment of hydrocephalus.